Endocrine Abstracts

Objective: The aim of this study was to determine the frequencies of vitamin D receptor (VDR) Bsm1, Fok1, ApaI, TaqI and estrogen receptor α (ESR1) PvuII and XbaI polymorphisms in Romanian patients and to investigate their involvement in postmenopausal osteoporosis.Methods: The study was carried out on 82 postmenopausal women, aged over 60, divided into two groups: group 1-postmenopausal women with osteoporosis (34 subjects), group 2-postmenopausal ...

The suprachiasmatic nucleus (SCN) is the ‘master clock’ of the mammalian brain. It coordinates the peripheral clock in body, including the pineal clock that receives SCN input via a multisynaptic noradrenergic pathway. Melatonin is exclusively involved in signaling the ‘time of day’, ‘time of year’ to all tissues and is thus considered to be the chronological pacemaker or ‘zeitgeber’.Objective: To determine the chr...

Background: Idiopathic scoliosis is a pathological entity of unknown etiology, characterized by a three-dimensional deformity of the spine and a low bone mass. The exact mechanism of bone loss in idiopathic scoliosis is unknown yet. However is well known that RANKL is a potent stimulator of bone resorption by binding receptor activator of nuclear factor-kB (RANK) in the osteoclasts cell membrane. OPG is a decoy receptor for RANKL, which interferes with RANKL/RANK binding and i...

Background: ER-α gene (ESR1) polymorphisms have been associated with a variety of disorders including human infertility. In this study, we examined two polymorphisms of the estrogen receptor α (ESR1) gene, IVS-1 −397 T/C (dbSNP: rs2234693) and IVS-1 −351 A/G (dbSNP: rs9340799) in a sample of healthy women of reproductive age to determine whether are associated with hormonal levels for a better understanding of its biological actions in human development, ...

Background: Androgen receptor (AR) activity is modulated by the length of CAG-repeat polymorphism in exon 1. Published data suggest association between CAG-repeat alleles and PCOS, but not all studies confirmed this finding.Aim: To test association of AR alleles with PCOS and clinical and biochemical signs of hyperandrogenism.Study design: Case–control association study, approved by the institutional ethical committee, of 137 ...

Adolescent idiopathic scoliosis (IS) represents an evolutive disease that occurs in puberty and progresses till the skeletal maturation. The neuroendocrine hypothesis involving a melatonin deficiency as the source for IS is one of the proposed causes of this plurifactorial disease.Objective: To investigate the hormonal changes of both the gonadal and growth axis and circadian rhythmicity in subjects with adolescent idiopathic scoliosis compared to age ma...

Studies evaluated bone involvement in the metabolic control of fat cells. It has been reported that osteocalcin acts as a hormone in the body, causing beta cells in the pancreas to release more insulin, and at the same time directing fat cells to release adiponectin, which increases sensitivity to insulin.The aim: Of the study was to evaluate osteocalcin levels in subjects with metabolic syndrome compared with age and sex matched control groups.<p cl...

Objective: To explore if the polymorphisms of the estrogen receptor alpha gene, XbaI (IVS1-351 A/G) and PvuII (IVS1-397 T/C) are associated with age-dependent changes in hormone levels for a better understanding of the biological actions of estrogens.Subjects and methods: Subjects, both genders aged between 20 and 80 years were classified into two groups: reproductive age (1) and over 55 years (2). The study received the Ethical Committee approval. Morni...

Introduction: Congenital adrenal hyperplasia is a group of autosomal recessive diseases, caused by mutations in the enzymes implicated in the synthesis of cortisol. In females, the classical pattern is characterized by progressive virilisation, short stature and in severe cases, by salt wasting in the newborn.Results: We present the case of a 14 years old female patient, who was referred to our clinic for primary amenorrhea. Her personal and family histo...

Objective: The aim of this study is the characterizing of genetic variation in PvuII and XbaI polymorphisms of the ESR1 gene associated with age-dependent endocrine, metabolic and cognitive changes in a representative sample of Romanian population stratified by age and sex.Subjects and methods: Subjects, both genders aged between 20 and 80 yr were assigned to three lots 1) 177 subjects aged 55–80 years with moderately cognitive impairment (MCI) (MMS...